PARP Inhibitor are substances that that have an action on cancer cells
altering their ability to grow and replicate DNA. According to some
studies it should make chemotherapy more effective. The use of PARP
inhibitors has been discussed greatly over the last years, and also
its application with chemotherapy.
On recent news, we get the information that PARP inhibitors show
specificity for BRCA tumors. From Medpage Today we have the following
info:
An investigational cancer therapy demonstrated significant antitumor
activity in patients with BRCA1/2 mutations, according to the
investigators in the most recent string of favorable studies.
[...]only mutation carriers had responses to the oral inhibitor of
poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP). However,
the agent demonstrated activity in patients with breast, ovarian, and
prostate cancer.
Authors of the study said:
“This tumor-specific defect can be exploited by using PARP
inhibitors to induce selective tumor cytotoxicity, sparing normal
cells,PARP inhibition in these tumor cells with deficient
homologous-recombination repair generates unrepaired DNA single-strand
breaks that are likely to cause the accumulation of DNA double-strand
breaks and collapsed replication forks.”
_Related searches:_
*parp inhibitor clinical trials, parp inhibitors, bipar sciences,
parp, brca1*
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